"I've tried everything. Nothing works."
I hear this almost daily in my clinical practice. Ania from Poland said the exact same words when she came to see me—exhausted by years of trying to "be good" with food.
She had followed multiple diets, tried countless supplements, and done "everything right"—yet her weight, bloating, and frustration remained. Four weeks later, without changing her diet, Ania lost 3kg and 5cm off her waist.
What changed? We stopped guessing and started personalising her health with a holistic, root-cause approach.
The Real Problem With One-Size-Fits-All Diets
Most diets fail not because you lack willpower, but because generic advice ignores your biology. Personalised nutrition research now shows that people respond very differently to the same foods and diet plans, depending in part on their gut microbiome, metabolism, and lifestyle context.¹ ²
Here's what "one-size-fits-all" plans completely overlook:
- Your unique gut microbiome composition—the trillions of bacteria in your gut that help digest food, regulate immunity, and influence weight and mood.³ ⁴
- Your individual hormone patterns—including insulin, cortisol, thyroid, and sex hormones that shape appetite, fat storage, and energy.
- Your liver and detoxification capacity—how efficiently you process hormones, toxins, and metabolic byproducts.
- Your stress response and nervous system balance—chronic stress changes how your body uses fuel and stores fat through the gut–brain axis and stress hormones like cortisol.⁵
- Your redox balance—the ratio between harmful free radicals and your antioxidant defences, which influences inflammation, metabolic health, and cellular resilience.⁶
- Your ability to absorb nutrients efficiently—you are not only what you eat, but what you can digest, absorb, and use.
Two people can eat the same foods and follow the same plan and still get completely different results. That's not failure—that's individual physiology.
The Science Behind Personalisation (And Why Diets Struggle)
After years in clinical practice and hundreds of client journeys, one truth is clear:
Your gut microbiome is as unique as your fingerprint.
Studies show that baseline gut microbiota patterns can help predict who will respond best to particular dietary interventions, including weight-loss diets and fibre-rich plans.¹ ² ⁴ ⁷ Some people lose more weight on high-fibre diets, for example, when specific bacteria like Prevotella are more abundant in their gut.⁷
When a protocol "doesn't work," it's rarely because the basic science of nutrition is wrong—it's usually because the application wasn't personalised to that person's microbiome, metabolism, and lifestyle. Personalised gut health focuses on identifying your root imbalances and supporting your body accordingly, rather than chasing trends.
We also consider redox biology—the balance between oxidative stress and antioxidant defences. When oxidative stress is high and antioxidant status is low, metabolic pathways, mitochondrial function, and inflammation can be affected, making weight loss and energy regulation much harder.⁶ ⁸
The Rejuv Clinical Assessment Process
Step 1: Comprehensive Health & Lifestyle History
Before recommending anything, we look at the complete holistic picture. This includes:
- Digestive symptoms: bloating, reflux, constipation, loose stools, sugar or salt cravings.
- Energy levels across the day: morning fatigue, afternoon crashes, wired-at-night patterns.
- Sleep quality and recovery: how easily you fall asleep and stay asleep, and how refreshed you feel.
- Stress load and emotional resilience: how often your nervous system feels "on edge" or overwhelmed.
- Hormonal symptoms: cycle changes, PMS, perimenopause or menopause shifts, low libido.
- Redox balance: signs of oxidative stress such as frequent infections, slow recovery, skin issues, or chronic inflammation.⁶ ⁸
- Previous diets, supplements, and "failed" attempts—these often show what your body has already told you does not work.
These questions alone often reveal patterns that have been missed for years. Personally, when I'm under pressure, I still notice that my own sugar cravings and late-night screen-time can creep back in—these are essential clues that my nervous system and blood sugar need support, not more discipline.
Step 2: Functional Testing (When Appropriate)
When deeper insight is needed, we bring in functional testing to remove guesswork and provide objective data. This might include:
- Urine analysis to assess metabolic pathways, detoxification capacity, and markers related to oxidative stress and acid–alkaline balance.
- Blood work to evaluate nutrient status, blood sugar regulation, inflammation, thyroid, and other key markers.⁹
- Symptom-based clinical assessment to connect lab findings with how you actually feel day to day.
Tanja (Croatia)
"The urine test kit is an essential step you should start with. It's easy to use, and you get detailed feedback and recommendations from Dr. Simone. Don't skip this step."
Testing isn't about lab numbers for the sake of it; it's about using data to personalise your plan, monitor progress, and avoid unnecessary trial-and-error.
Step 3: Personalised Protocol Design
Each protocol is built specifically for the individual, but the core pillars are usually similar:
- Targeted supplementation to support gut health, blood sugar balance, adrenal function, detoxification, and antioxidant status where needed.³ ⁶ ⁹
- Strategic dietary adjustments—not extreme restriction—to stabilise blood sugar, reduce inflammation, and feed your beneficial gut microbes.³ ⁴ ⁷
- Lifestyle and nervous system support, such as simple breathwork, gentle movement, and realistic sleep hygiene practices.
- Clear expectations and timelines so you know what to focus on now, and what changes may take longer.
There are no copy-and-paste plans; even within the same household, partners often end up with different protocols. In my own life, I adjust my routine across the year—during busy seasons I lean more on adrenal and nervous-system support, while in quieter seasons I focus more deeply on gut and detox work.
Step 4: Monitoring & Adjusting
Your body changes—so your protocol must adapt. This is where long-term success happens.
- Regular check-ins to see how you feel, not just what the scale says.
- Progress tracking using symptoms, measurements, and (where appropriate) repeat testing.
- Adjustments based on real results, not perfectionism or pressure.
This ongoing, responsive approach is what allows you to move from short-term "diet sprints" into sustainable, abundant health.
Real Client Transformations (De-Identified Case Snapshots)
Ania—Poland
Challenge:
"After many diets and various supplements, nothing showed visible results."
Assessment highlights:
- Blood sugar dysregulation.
- Metabolic slowdown.
- Water retention and bloating.
Personalised protocol focus:
- Blood sugar support.
- Gentle metabolic support (including green coffee and thermogenic herbs where appropriate).¹⁰
- Fluid balance support.
Results (4 weeks):
✔ 3kg weight loss
✔ 5cm reduction in waist circumference
✔ No diet change—the shifts came from correcting underlying imbalances.
Ania says:
"I highly recommend them!"
Ronja—Metabolism Reset in Her 40s
Challenge:
Slowing metabolism, weight creeping up, and fatigue despite "healthy eating."
Assessment:
Urine testing revealed specific metabolic and oxidative-stress-related imbalances that were blocking progress.⁶ ⁸
Protocol focus:
- Thermogenic and metabolic support to improve energy expenditure.¹⁰
- Fully personalised guidance to match her work schedule, sleep, and hormonal changes.
Results:
"My metabolism is back to what it was in my 20s—even though I'm now in my 40s."
Validation:
Blood tests confirmed physiological improvements in key markers.
Heli—Candida Recovery Journey
Challenge:
Persistent candida overgrowth symptoms, bloating, fatigue, and recurrent discomfort.
Assessment:
Urine testing combined with detailed symptom analysis to understand gut, immune, and detox patterns.³ ⁹
Protocol focus:
- Targeted anti-candida support.
- Personalised anti-candida nutrition and gut-rebuilding approach to avoid ongoing restriction.³
Results:
✔ Clear improvements within 1 month, with continued progress over time.
Heli shares:
"I would highly recommend the urine test to confirm what you need. Simoné has been absolutely amazing—her advice has been spot on. 10 ⭐!"
Why Personalisation Works (And Generic Diets Don't)
Personalised gut and holistic health:
- Addresses your specific imbalances, not generic "gut health."³ ⁴
- Targets your metabolic patterns, not population averages.² ³
- Supports your unique microbiome with tailored fibre, polyphenols, and (when needed) probiotics.¹ ³ ⁴
- Fits your lifestyle, which makes it sustainable instead of all-or-nothing.
- Tracks your progress and adjusts, so your plan evolves with you.
This is precision wellness—not trial and error. It sits at the intersection of nutrition, gut microbiology, psychoneuroimmunology (the communication between the nervous and immune systems), and lifestyle medicine. Still, in practical terms, it simply means: we listen carefully to your body and work with it, not against it.
3 Questions to Ask Before Starting Any Protocol
Before you follow any plan you see online, ask yourself:
- Is this based on my personal assessment—or generic advice?
- Does it address my likely root causes—or just symptoms and surface goals?
- Is there a way to objectively measure my progress over time?
If the answer is "no," it's probably another short-term fix dressed up as the solution. Personally, I still catch myself tempted by the newest "quick reset," but experience has taught me that foundations and personalisation always win in the long run.
Wellness Warrior Spotlight: Ania (Poland)
Ania's success was deliberate and personalised—not just another diet. It was about finally listening to her body and working with it, instead of fighting hunger, fatigue, and cravings.
When we supported her blood sugar, fluid balance, metabolism, gut health, and redox balance, her body responded quickly because it finally had what it needed.
Your Next Step
If you're tired of trying everything and feeling stuck, your next step doesn't have to be more willpower. It can be more clarity.
Instead of asking, "Which diet should I try next?" you might ask, "What is my body actually telling me—and what are my unique imbalances?" From there, a personalised plan becomes far more potent than another set of rules.
Your Personalised Wellness Invitation
If this resonates with your experience of "trying everything," consider this an invitation to pause the dieting cycle and get curious about your unique biology. Your gut, hormones, nervous system, and redox balance are constantly sending signals—together, we can learn to read them.
A simple next step is to complete the Rejuv Wellness Profile, which helps you identify patterns and priorities so you stop guessing. From there, you can explore personalised support—whether that's focused on gut health, metabolism, adrenal balance, immune support, or cellular resilience—and move towards a way of eating and living that truly fits you.
You deserve a plan that honours your story, your body, and your season of life—not another generic diet that treats you like everyone else.
References
- Hernández-Calderón P, Lira-Noriega A, Solórzano-Vargas RS, et al. The microbiota composition drives personalised nutrition: a new perspective in obesity treatment. Nutrients. 2022;14(19):4047. https://pmc.ncbi.nlm.nih.gov/articles/PMC9537590/
- Martinsen T, Kullenberg de Gaudry D, Myhrstad MCW, et al. Key evidence for personalised nutrition: a review of intervention studies. Food & Function. 2026;17(1):12–28. https://pubs.rsc.org/en/content/articlehtml/2026/fo/d5fo02969d
- Liu BN, Liu XT, Liang ZH, Wang JH. Gut microbiota in obesity. World Journal of Gastroenterology. 2021;27(25):3310–3329. https://pmc.ncbi.nlm.nih.gov/articles/PMC8291023/
- Kviatcovsky D, Batista M, Zmora N. Gut microbiome and its potential link to personalised nutrition. Clinical Nutrition ESPEN. 2021;44:405–414. https://www.sciencedirect.com/science/article/abs/pii/S2468867321000572
- Foster JA, Neufeld K-AM. Gut–brain axis: how the microbiome influences anxiety and depression. Trends in Neurosciences. 2013;36(5):305–312. https://pubmed.ncbi.nlm.nih.gov/23384445/
- McBeth A, Figueroa C. Balancing oxidative stress: how the gut microbiome influences redox homeostasis. Journal of Restorative Medicine. 2025;14(2):45–62. https://restorativemedicine.org/journal/balancing-oxidative-stress-gut-microbiome-redox-homeostasis/
- Roager HM, Licht TR. Personal diet–microbiota interactions and weight loss. Annual Review of Nutrition. 2022;42:365–386. https://pubmed.ncbi.nlm.nih.gov/35258446/
- Sarmiento-Andrade Y, Castro-Barquero S, Ruiz-León AM, et al. Gut microbiota and obesity: New insights into a complex relationship. Frontiers in Nutrition. 2022;9:1018212. https://www.frontiersin.org/articles/10.3389/fnut.2022.1018212/full
- Trujillo MC, Munoz R, Patel A. Personalised nutrition program for microbiome restoration and sustainable weight management. Journal of Integrative and Functional Nutrition. 2025;3(1):15–32. https://nsuworks.nova.edu/cgi/viewcontent.cgi?article=1033&context=hpd_com_nutrition/
- Onakpoya IJ, Terry R, Ernst E. The use of green coffee extract as a weight loss supplement: a systematic review and meta-analysis. Gastroenterology Research and Practice. 2011;2011:382852. https://pubmed.ncbi.nlm.nih.gov/20871849/
